Macroglobulinemia in a child with acute leukemia.
نویسندگان
چکیده
A 1 2-yr-old boy with acute leukemia was globulin were found in the patient’s serum found to have paraproteinemia and Benceand urine. Electron microscopic and imJones proteinuria. The paraprotein was munofluorescence studies provided cvicharacterized as immunoglobulin M, type i dence of the presence of lymphoid leukemia and the Bence Jones protein as free cells apparently responsible for the producK-chains. Increased amounts of p2-microtion of the paraprotein. M ONOCLONAL GAMMOPATHY, usually found in multiple myeloma and Waldenstr#{246}m’s macroglobulinemia, has been observed in other proliferative disorders including leukemias. The occurrence of paraproteins of the three main immunoglobulin classes in chronic lymphocytic and myelocytic leukemias is well documented)7 In children paraproteinemia is extremely rare. Only a few cases describing its association with childhood leukemia are on record, none of which are of the 1gM class.8’#{176} This paper describes a unique case of K-type macroglobulinemia with Bence Jones proteinuria in a child with acute leukemia.
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P ARAPROTEINS* ARE generally found in the serum in patients suffering from multiple myeloma or Waldenstr#{246}m’s macroglobulinemia. Recently, however, there have been a number of reports on patients in whom paraproteinemia#{176} was found in association with a myeloproliferative disorder such as polycythemia, erythroleukemia, acute myeloblastic and lymphoblastic leukemia, and chronic myelocyti...
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ورودعنوان ژورنال:
- Blood
دوره 43 2 شماره
صفحات -
تاریخ انتشار 1974